Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6.The hydrophobicity of Wnt proteins has complicated their purification and limited their use in basic research and as therapeutics.We describe modular visual comfort primitive swing arm t